The Histone Variant H3.3 Is Enriched at Drosophila Amplicon Origins but Does Not Mark Them for Activation
Eukaryotic DNA replication begins from multiple origins.The origin recognition complex (ORC) binds origin DNA and scaffolds assembly of a prereplicative complex (pre-RC), which is subsequently activated to initiate DNA replication.In multicellular eukaryotes, origins do not share a strict DNA consensus sequence, and their activity changes in concer